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Qxd 4105 12:31 PM Page 142 76 SECTION I INTRODUCTION TO MOLECULAR MEDICINE Class Growth factors Receptor tyrosine kinases Non-receptor tyrosine kinases Cell surface proteins GTPases Protein kinases Transcription factors Cell-cycle factors DNA repair Programmed cell death Oncogene sis int-2 erbB-2 ret abl src DCC APC ras Gsα mos raf jun myc Rb p53 ATM hMSH2 Bcl-2 Function Homologous to the β chain of platelet-derived growth factor (PDGF) Integration site for MMTV; fibroblast growth factor-3,4 (FGF-3,4) genes Orphan receptor related to the epidermal growth factor receptor (EGF-R) Activated form of tyrosine kinase; binds glial derived nerve growth factor Translocates to bcr; interacts with cell cycle proteins Membrane associated tyrosine kinase; activates mitogenic signaling cascades Deleted in colorectal cancer gene involved in cell adhesion Adenomatous polyposis gene that interacts with β-catenin and E-cadherin Activates signaling cascades including MAPKsERKs Activates adenylyl cyclase A MEK-like enzyme Serine kinase in the ras pathway B-Zip protein that complexes with fos to form AP-1 bHLH protein that regulates cell cycle factors Retinoblastoma undergoes phosphorylation to regulate cell cycle progression Transcription factor that regulates cell-cycle genes and apoptosis Ataxia-telangiectasia gene involved in cell-cycle checkpoints and p53 directed apoptosis Human mutS homolog involved in DNA mis-match repair Blocks apoptosis; interacts with other cell proteins such as Bax to control apoptosis Figure 7-5 Table 7-2 Functional Classes of Oncogenes and Tumor Suppressor Genes The cycle of ras activation and effect of mutations.
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